AG Kreikemeyer


Current research projects on group A streptococci in the institute are

  • molecular characterization of S. pyogenes surface-associated adhesins, secreted enzymes and toxins

  • regulation of virulence gene expression and phase switching

  • system biology approach to elucidate the S. pyogenes whole cell metabolism and its association to virulence

  • bacteria-host interactions during adherence, internalization, and intracellular persistence as well as during evasion from the host cell

  • characterization of the molecular biology of S. pyogenes monospecies biofilms

  • interactions between S. pyogenes and other bacterial species of the human oral cavity and skin in the course of mixed species biofilm formation

  • effects of life cell / killed S. pyogenes preparations as adjuvants in experimental tumor therapy


Current research projects on biofilms in the institute are

  • set-up and optimization of culture conditions for mixed species biofilms with periodontal pathogens

  • current optimization of culture techniques for investigating pathogens forming biofilms on implant materials

  • in situ hybridization, metabolic markers and antibody techniques for the visualization of biofilm bacteria

  • microscopic techniques to study the three dimensional structures of biofilms

  • gene expression measurements and proteomics of biofilm-organized bacteria

  • prevention / change of biofilm growth by surface modifications and treatments with antiseptics or probiotics