In cooperation with modeller groups we aim to understand the metabolic processes enabling gram-positive homfermentative lactic acid bacteria such as Streptococcus pyogenes andEnterococcus faecalis to colonize (or invade) the human host.

We experimentally support the modelling groups in reconstructing the metabolic networks of those bacteria and construct genome-scale metabolic models.
Based on the models, we try to identify potential new drug targets interfering with metabolic processes specific and vital for the bacteria.

Streptococcus pyogenes is a major gram positive pathogen causing diseases ranging from mild superficial skin and throat infections (Impetigo contagiosa, pharyngitis/”strep throat”) to more severe up to life threatening infections (scarlet fever, necrotizing fasciitis, sepsis, toxic-shock-like syndrome).

Numerous virulence factors enable the bacteria to cause those diseases.
We work on the functional characterization of exo-enzymes that may play a role in S. pyogenes virulence. 

Mesenchymal stem cells are present in numerous mesodermal tissues.

Therefore, during infections bacteria encounter these cells. In a collaboration with PD Dr. Kirsten Peters (Cell Biology Group of the Rostock University Medical Centre) and Dr. Sonja Oehmcke-Hecht (IMIKRO) we investigate the impact of pathogenic bacteria and their surface structures on adipose-derived mesenchymal stem cells in terms of viability, proliferation, immunological activation, and differentiation.

Microbial enzymes converting nutrients essential for growth of tumor cells are promising candidates in cancer therapy.

In collaboration with Dr. Claudia Maletzki (Molecular Oncology and Immune Therapy group of the Rostock University Medical Centre) we work on the application of arginine-famishment of solid tumors using bacterial arginine-degrading enzymes.