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Infection Immunology


Importance

Der Schlüssel zur Entwicklung neuer innovativer Therapieformen gegen Infektionen liegt im Verstehen der Funktionsprinzipien der Immunabwehr.

Die Kernfrage ist deshalb, wie das angeborene Immunsystem auf bakterielle Infektionserreger reagiert.

Main Topics

The haemostatic system comprises platelet aggregation, coagulation and fibrinolysis and is a host defense mechanism that prevents bleeding after vessel injury. During systemic infection complications occur because of a dysregulated coagulation system. While this is widely accepted, an important role of the coagulation system in the early host response to infectious diseases has been only recently begun to be appreciated. The induction of coagulation entraps microorganisms in a fibrin clot and inhibits pathogen dissemination and survival, indicating that interaction of bacteria with the coagulation system may be an integral part of the innate immune response.

Our current and future research is focused on a molecular understanding of how the innate immune system responds to bacterial invaders, and which strategies are used by bacteria to subvert immune defense. In addition, we study development and functions of infected monocytes, a type of white blood cells and part of the innate immune system. Such studies will expose fundamental functions of the immune system and identify new targets for the treatment of severe infectious diseases.

Methods

  • Anzucht von Bakterien
  • Zellkultur
  • Anzucht und Aufreinigung von Viren
  • Gerinnungsassays
  • Substratassay
  • Semiquantitative Western Blot Analyse
  • ELISA
  • Surface Plasmon Resonance
  • TaqMan PCR
  • Rasterelektronenmikroskopie
    (in Zusammenarbeit mit dem Elektronenmikroskopischen Zentrum, UMR)
  • Transmissionselektronenmikroskopie
    (in Zusammenarbeit mit dem Elektronenmikroskopischen Zentrum, UMR)
  • Fluoreszensmikroskopie
  • in vivo Infektionsmodelle (Maus)

Working groups in this area