Systemic infections trigger activation of coagulation and contact pathways, which both restrict pathogen dissemination and contribute to disease pathology. Our work elucidates how bacteria and viruses interact with these haemostatic defenses and how their dysregulation drives severe infectious disease

Funding

DFG - Projektnummer 201106193

DFG - Projektnummer 316733765

Koinfekt - Forschungsprojekt im Rahmen der Landesexzellenzinitiative Mecklenburg-Vorpommern, gefördert von der Europäischen Union (ESF)

Infection sites are characterized by the activation of neutrophil, coagulation, and contact system proteases, generating a highly dynamic proteolytic microenvironment. We investigate how these host enzymes modify bacterial virulence traits, biofilm behavior, and invasive potential, thereby influencing whether infections remain localized or progress to severe disease. Understanding these mechanisms may reveal new opportunities for targeted therapeutic intervention.