Current research projects on group A streptococci in the institute are

• molecular characterization of S. pyogenes surface-associated adhesins, secreted enzymes and toxins

• regulation of virulence gene expression and phase switching

• system biology approach to elucidate the S. pyogenes whole cell metabolism and its association to virulence

• bacteria-host interactions during adherence, internalization, and intracellular persistence as well as during evasion from the host cell

• characterization of the molecular biology of S. pyogenes monospecies biofilms

• interactions between S. pyogenes and other bacterial species of the human oral cavity and skin in the course of mixed species biofilm formation

• effects of life cell / killed S. pyogenes preparations as adjuvants in experimental tumor therapy