Current research projects on group A streptococci in the institute are

  • molecular characterization of S. pyogenes surface-associated adhesins, secreted enzymes and toxins

  • regulation of virulence gene expression and phase switching

  • system biology approach to elucidate the S. pyogenes whole cell metabolism and its association to virulence

  • bacteria-host interactions during adherence, internalization, and intracellular persistence as well as during evasion from the host cell

  • characterization of the molecular biology of S. pyogenes monospecies biofilms

  • interactions between S. pyogenes and other bacterial species of the human oral cavity and skin in the course of mixed species biofilm formation

  • effects of life cell / killed S. pyogenes preparations as adjuvants in experimental tumor therapy